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4 Best Apigenin Supplements of 2025 [Compared]

Emma-Kate Lidbury

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Apigenin is a natural flavonoid compound found in chamomile, parsley, celery, oregano, and other plants, herbs, and vegetables. It is known for its antioxidant and anti-inflammatory properties.


It has been studied for its potential benefits in promoting relaxation, supporting brain health, and modulating immune function. Due to its calming effects, apigenin is often associated with chamomile tea, which is commonly used for relaxation and sleep support.


Apigenin has been studied for its potential benefits in sleep quality and neuroprotection. This 2024 study found that the flavonoid polyphenols apigenin and naringenin led to improvements in sleep quality, while  this 2020 study  showed how it can help protect against the inflammatory damage of neurodegenerative disorders. 


Whether you're looking for the highest-quality, independently tested supplements, the best value, or specific dosage requirements, we've analyzed various brands to help you find an apigenin supplement that matches your needs. We'll begin our list with our own apigenin supplement at Momentous.


1. Momentous Apigenin


Key Things to Know About This Product

  • Third-Party Tested: Yes, NSF Certified for Sport

  • Money-Back Guarantee: Yes

  • Gluten Free: Yes

  • GMO Free: Yes

  • Vegan: Yes


Product Details:

  • Price: $22.95

  • Apigenin sourcing: Grapefruit

  • Number of Servings: 60

  • Amount of apigenin per serving: 50 mg

  • Serving Size: 1 capsule

  • Subscription: Yes - 25% discount on first order, 10% thereafter

  • Free shipping: Yes (orders over $75)


Pros:

  • High-quality ingredients

  • NSF Certified for Sport certification

  • Highly rated by customers


Cons:

  • One of the more expensive options

  • Potential grapefruit interactions - grapefruit compounds can interfere with certain medications, so check with a doctor if you’re on prescription medications

I started taking Momentous Apigenin after hearing about its benefits for sleep and relaxation. As someone who’s never been the greatest sleeper, I was looking for a natural solution that wouldn’t leave me feeling groggy the next morning. After using it for a few weeks, in tandem with Momentous Magnesium L-Threonate and Momentous L-Theanine (as part of the Momentous Sleep pack), I can confidently say it’s brought huge improvements to the quality and depth of my sleep.


The first thing I noticed was a subtle but noticeable calming effect about an hour after taking it. It didn’t knock me out like melatonin sometimes does, but together with other good sleep hygiene practices, it helped me unwind naturally. I found myself falling asleep faster and waking up feeling more refreshed. Unlike other sleep aids, I didn’t experience any weird dreams or morning sluggishness.


Beyond sleep, I’ve also noticed that I feel less anxious during the day. It wasn’t necessarily a benefit I was expecting, but it makes sense given apigenin’s ability to modulate GABA activity in the brain. It’s almost like a mild, natural stress reliever.


The only downside? It’s a bit pricey compared to some other apigenin supplements you can find. However, Momentous prioritizes quality and third-party testing, and this product’s NSF Certified for Sport certification helps me feel confident in what I’m taking. If you’re looking for a reliable, clean, and effective apigenin supplement, this is worth considering.


As it is sourced from grapefruit (which some people prefer over chamomile extract), it is advisable to check with a healthcare professional before taking it if you’re on prescription medications that may cause contraindications.


Overall, I’m really happy with Momentous Apigenin. It’s helped me sleep better, feel more relaxed, and even improved my focus during the day. It’s certainly worth trying for yourself—especially if you struggle with sleep or stress.

2. VitalityPRO Apigenin

Key Things to Know About This Product

  • Third-Party Tested: Yes

  • Money-Back Guarantee: Yes

  • Gluten Free: Yes

  • GMO Free: Yes

  • Vegan: Yes


Product Details:

  • Price: $32

  • Apigenin sourcing: Grapefruit peel

  • Number of Servings: 90

  • Amount of apigenin per serving: 100 mg

  • Serving Size: 1 capsule

  • Subscription: Yes - save 5%

  • Free shipping: Yes - on orders $150+


Pros:

  • High-potency dosage

  • Third-party tested with certificates of analysis

  • Great customer service


Cons:

  • Price

  • Potential grapefruit interactions - grapefruit compounds can interfere with certain medications, so check with a doctor if you’re on prescription medications


VitalityPRO’s Apigenin is a premium product that customers love for its high-quality ingredients and third-party testing. Each VitalityPRO product comes with a certificate of analysis for full manufacturing and quality transparency. Customers also love this brand’s fast and friendly customer service.


With 100 mg of apigenin per capsule, it offers a higher dosage than the Momentous product yet comes with a higher price per serving ($0.36 per serving). And as the recommended dosage for helping with sleep is up to four capsules, this could ultimately make the price per serving even less cost effective.


As this product is sourced from grapefruit peel it is recommended that anyone taking prescription medications checks with a doctor before using. 

3. ProHealth Longevity Full Spectrum Apigenin Plus

Key Things to Know About This Product

  • Third-Party Tested: Yes

  • Money-Back Guarantee: Yes

  • Gluten Free: Yes

  • GMO Free: Yes

  • Vegan: Yes


Product Details:

  • Price: $45.74

  • Apigenin sourcing: Natural apigenin, parsley powder, black pepper

  • Number of Servings: 30

  • Amount of apigenin per serving: 500 mg

  • Serving Size: 2 capsules

  • Subscription: Yes - save 30%

  • Free shipping: Yes - on orders $30+


Pros:

  • High-potency dosage

  • Third-party tested with certificates of analysis

  • Strong subscription savings & low shipping threshold


Cons:

  • Price

  • Given the high potency dose, it might not be ideal for first-time apigenin users


ProHealth Longevity offers pharmaceutical grade supplements that are science-backed and formulated with premium ingredients. However, just know that this comes with a hefty price tag. The Full Spectrum Apigenin Plus has a cost per serving of $1.52, which is more than five times the cost of the other apigenin supplements on this list.


With a 500 mg dose of apigenin per serving, it’s a higher-potency dosage, which might not be ideal for first-time users. Each product comes with a certificate of analysis to ensure transparency. Customers love the quality, bioavailability, and efficacy of this product, saying it has made noticeable improvements to their sleep, mood, stress levels, and healthy aging. Given the cost, though, it is not a product for those looking for more wallet-friendly options. 

4. Double Wood Supplements Apigenin

Key Things to Know About This Product

  • Third-Party Tested: Yes

  • Money-Back Guarantee: Yes

  • Gluten Free: Yes

  • GMO Free: Yes

  • Vegan: Yes


Product Details:

  • Price: $19.96

  • Apigenin sourcing: Chamomile

  • Number of Servings: 120

  • Amount of apigenin per serving: 50 mg

  • Serving Size: 1 capsule

  • Subscription: Yes - save 20%

  • Free shipping: Yes


Pros:

  • Cost effective, good for those on a budget

  • Third-party tested


Cons:

  • Not NSF-certified


Double Wood Apigenin is a great choice for anyone looking for a decent apigenin capsule while also being budget conscious. While it lacks NSF Certified for Sport certification, which Momentous has, their products are made in the US in GMP-certified facilities.


Customer reviews report high degrees of satisfaction with both the quality of the product and the cost of it, with many saying it’s helped improve their sleep more than prescription sleep medications have. It doesn’t lead to next-day grogginess and helps provide a sense of calm when winding down in the evening. For those looking for a cost-effective apigenin supplement, this Double Wood product is a good place to start.

Emma-Kate Lidbury

Emma-Kate Lidbury

Emma-Kate Lidbury is a freelance writer and editor with 20 years of experience working in the health and fitness world.